This study examines the impact of credit risk and liquidity risk on the profitability of the banks in Pakistan before and after the implementation of the Basel II policy in Pakistani Banks. For this purpose, five private commercial banks of Pakistan selected as the sample of our study. The balanced panel data of these banks for ten years (2006-2015) is used to analyze the model. The data is collected from the annual reports of the selected banks. The impact of pre and post-Basel-II policy implementation is also measured using four years (2006-2009) as pre-Basel-II and six years (2010-2015) as post-Basel-II to compare the impact of Basel-II implementation in the banks. The regression model estimation technique is used, which is selected based on the unit root test. The fixed effect and random effect models are used based on the Hausman test to estimate profitability determinants. The models are applied in three phases as the whole period, pre-Basel-II, and post-Basel-II implementation period. Further studies could be developed by adding more variables to the regression model to check their impact on bank profitability. The sample size can be increased to all commercial banks, and further, this study can also be discussed in Islamic banking and microfinance institutions. Further, the dependent variables could also be increased to enhance the results of bank profitability. The number of observations could be improved to describe the risk management more prudent than this. The study suggests that banks have to follow strategies that provide adequate diversification in credit risk and liquidity risk management to mitigate these risks and enhance the profitability. It is further recommended that adopting a sound risk management system and strong corporate governance will reduce the credit risk and liquidity risk and ultimately improve the profitability of banks in Pakistan.